Long-term clinical outcomes of allograft-prosthetic reconstruction for tumours of the extremities.

Cohort studyInternational orthopaedics· May 2026

Long-term clinical outcomes of allograft-prosthetic reconstruction for tumours of the extremities.

Philip T J Sanders, Sjors F van de Vusse, Giovanni Simonis … Michaël P A Bus

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OrthopedicsCohort studyClinical practiceQ1IF 2.7

Allograft-prosthetic reconstructions had a 28.6% mechanical failure risk by 25 years.

Long-term clinical outcomes of allograft-prosthetic reconstruction for tumours of the extremities.

Philip T J Sanders … Michaël P A Bus

International orthopaedics · May 2026 · Q1 in Orthopedics

Purpose

This study evaluated the incidence of mechanical and non-mechanical complications, risk factors for complications, and the cumulative incidence of reconstruction failure following allograft-prosthetic composites reconstruction for extremity tumours with a minimum follow-up of ten years.

Methods

We retrospectively reviewed 64 allograft-prosthetic composites with at least ten years follow-up in our centre.

n = 64 APC

Results

nearly 3 in 10 reconstructions mechanically fail by 25 years

15.6%

5 years

21.9%

10 years

28.6%

25 years

More results

Instability occurred in nine reconstructions (14%).

Non-union was observed in nine reconstructions (14%).

Implant loosening occurred in seven reconstructions (11%) after a median of 14 years (range 2-18 years).

Allograft collapse occurred in 13 reconstructions (20%) after a median of three years (range 1-15).

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Conclusion · 1 of 3

Allograft-prosthetic composites are associated with a considerable risk of both early and late complications.

Conclusion · 2 of 3

Non-union and infection predominate in the early postoperative period, whereas aseptic loosening and fractures are the main causes of late failure, occurring up to 18 years after surgery.

Conclusion · 3 of 3

These findings suggest that the routine use of allograft-prosthetic composites for periarticular reconstruction after tumour resection should be reconsidered.

Long-term clinical outcomes of allograft-prosthetic reconstruction for tumours of the extremities.

Long-term clinical outcomes of allograft-prosthetic reconstruction for tumours of the extremities.

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