Calibration-Free Estimation of Cerebrovascular Reactivity From Resting-State BOLD fMRI Using Reconstructed…

Cohort studyMagnetic resonance in medicine· Aug 2026

Calibration-Free Estimation of Cerebrovascular Reactivity From Resting-State BOLD fMRI Using Reconstructed Respiratory Fluctuations.

Abdoljalil Addeh, Ethan Church, Muhammad Mahajna … M Ethan MacDonald

NeuroradiologyCohort studyQ1IF 3.4

Calibration-free fMRI method spatially matches gold-standard gas-challenge cerebrovascular reactivity maps.

Calibration-Free Estimation of Cerebrovascular Reactivity From Resting-State BOLD fMRI Using Reconstructed Respiratory Fluctuations.

Abdoljalil Addeh … M Ethan MacDonald

Magnetic resonance in medicine · Aug 2026 · Q1 in Radiology

Purpose

Cerebrovascular reactivity (cerebrovascular reactivity) provides an important index of vascular health and is conventionally quantified using a hypercapnic gas or breath-hold challenge in conjunction with blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD-fMRI).

Methods

The method leverages a previously validated machine learning-based respiratory variation (respiratory variation) reconstruction approach to recover respiratory dynamics directly from BOLD-fMRI time series.

n = 83 healthy young adults

Results

spatial pattern matched gold-standard maps closely, values near 1 mean stronger match

0.61r

Overall

0.72r

High respiratory varia

“

Conclusion

Collectively, these results establish a reliable, non-invasive, and calibration-free strategy for cerebrovascular reactivity mapping, enabling broader deployment in both research and clinical environments where gas-challenge protocols and physiological monitoring are impractical.

Calibration-Free Estimation of Cerebrovascular Reactivity From Resting-State BOLD fMRI Using Reconstructed Respiratory Fluctuations.

Calibration-Free Estimation of Cerebrovascular Reactivity From Resting-State BOLD fMRI Using Reconstructed Respiratory Fluctuations.

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