MANAGEMENT OF CLOSTRIDIOIDES DIFFICILE INFECTION IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND…

Meta-analysisArquivos de gastroenterologia· 2026

MANAGEMENT OF CLOSTRIDIOIDES DIFFICILE INFECTION IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANTIBIOTIC EFFICACY.

Isadora Brandão Pelucio, Carla Malaguti, Túlio Medina Dutra de Oliveira … Júlio Maria Fonseca Chebli

Colon & Rectal SurgeryMeta-analysisTreatmentQ3IF 0.9

Vancomycin trended toward lower C difficile recurrence than metronidazole in inflammatory bowel disease

MANAGEMENT OF CLOSTRIDIOIDES DIFFICILE INFECTION IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANTIBIOTIC EFFICACY.

Isadora Brandão Pelucio … Júlio Maria Fonseca Chebli

Arquivos de gastroenterologia · 2026 · Q3 in Gastroenterology

Background

Clostridioides difficile infection (clostridioides difficile infection) is a significant complication in patients with inflammatory bowel disease (inflammatory bowel disease), often associated with higher recurrence rates, increased morbidity, and complex therapeutic decision-making.

Purpose

To evaluate the efficacy of different antibiotic therapies for clostridioides difficile infection in patients with inflammatory bowel disease.

Methods

A systematic review and meta-analysis were conducted according to PRISMA 2020 guidelines.

n = 643 patients

Results

vancomycin trended toward fewer recurrences, but difference not statistically significant

OR 0.55 (95% CI 0.15 to 1.99)

CI crosses the null - not significant

More results

Nine studies involving 643 patients met inclusion criteria.

Recurrence occurred in 17.4% of patients treated with metronidazole and 8.2% of those treated with vancomycin.

Mortality was low and similar between groups, and colectomy occurred exclusively in patients with ulcerative colitis.

More results

Data on clinical success and adverse events were heterogeneously reported and summarized narratively.

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Conclusion · 1 of 2

Vancomycin may be associated with lower recurrence in higher-risk inflammatory bowel disease patients; however, available evidence remains limited and heterogeneous.

Conclusion · 2 of 2

Treatment decisions should be individualized, and further prospective, inflammatory bowel disease-specific studies are needed to clarify optimal management strategies.

MANAGEMENT OF CLOSTRIDIOIDES DIFFICILE INFECTION IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANTIBIOTIC EFFICACY.

MANAGEMENT OF CLOSTRIDIOIDES DIFFICILE INFECTION IN INFLAMMATORY BOWEL DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANTIBIOTIC EFFICACY.

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