Local field potentials for target localization in centromedian deep brain stimulation for epilepsy.
Dual-peak theta and beta local field potentials mark centromedian-parafascicular thalamic contacts in epilepsy deep brain stimulation.
Local field potentials for target localization in centromedian deep brain stimulation for epilepsy.
To evaluate whether local field potential (local field potential) spectral profiles can serve as a candidate "spectral fingerprint" for physiological confirmation of centromedian-parafascicular (centromedian-parafascicular) targeting during thalamic deep brain stimulation (deep brain stimulation) for drug resistant epilepsy (drug resistant epilepsy).
This is a retrospective study of 10 patients (20 leads) who underwent CM-DBS implantation for drug resistant epilepsy at a single tertiary center.
Contacts were distributed as follows: 50 in the CM, 16 in the Parafascicular (Pf), 15 in the Centrolateral, 8 in the Mediodorsal, and 7 in the Ventrolateral (ventrolateral) nuclei.
Single-peak profiles showed no significant association with specific nuclei ( p = 0.871).
Contacts overlapping other thalamic nuclei more frequently exhibited narrow 10-15 Hz peaks ( p = 0.005) or triple-peak profiles ( p = 0.02), suggesting mixed structural contributions.
A dual- band candidate spectral pattern consisting of theta/low alpha and high beta peaks was associated with the centromedian-parafascicular region in this cohort.
This finding provides early evidence supporting the feasibility of incorporating passive local field potential recordings as a physiologic marker of target engagement.