Clinical Presentation of a Patient With Hemochromatosis After Bariatric Surgery With HFE (H63D) Mutation. | ScholarDeck

Paper

Clinical Presentation of a Patient With Hemochromatosis After Bariatric Surgery With HFE (H63D) Mutation.

New research · Surgery

Journal of investigative medicine high impact case reports · 3w

Case reportJournal of investigative medicine high impact case reports· 2026

Clinical Presentation of a Patient With Hemochromatosis After Bariatric Surgery With HFE (H63D) Mutation.

Samuele Petridis, Karla Baez Rodriguez, Naresh Punjabi … Ron T Varghese

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Bariatric & Metabolic SurgeryCase reportDiagnosisQ3IF 0.7

Transferrin saturation was elevated despite normal ferritin in H63D-linked iron overload.

Clinical Presentation of a Patient With Hemochromatosis After Bariatric Surgery With HFE (H63D) Mutation.

Samuele Petridis … Ron T Varghese

Journal of investigative medicine high impact case reports · 2026

Background

Hereditary hemochromatosis (hemochromatosis) is a genetic disorder characterized by excessive intestinal iron absorption, most associated with HFE C282Y homozygosity.

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Results

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iron transport nearly saturated despite normal ferritin

More results

In contrast, H63D homozygosity is considered a low-penetrance genotype that rarely leads to clinically significant iron overload.

Despite an initial 97-lb postoperative weight loss, he experienced significant weight regain along with fatigue, decreased libido, and skin darkening.

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FibroScan revealed F3 fibrosis and grade 3 steatosis, consistent with advanced metabolic dysfunction-associated steatotic liver disease.

Genetic testing confirmed H63D homozygosity.

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Conclusion

Clinicians should maintain vigilance for atypical presentations of hemochromatosis in individuals with metabolic dysfunction or prior bariatric surgery.

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