Albumin-Anchored Thromboinflammatory Ratios Provide Modest Incremental Prognostic Value Beyond Clinical…

Cohort studyNeurocritical care· Aug 2026

Albumin-Anchored Thromboinflammatory Ratios Provide Modest Incremental Prognostic Value Beyond Clinical Severity Scores in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study.

Omer Aykanat, Aykut Sezer, Yucel Duzenli, Lokman Bayrak

CerebrovascularCohort studyPrognosisQ1IF 3.3

Adding D-dimer-to-albumin ratio modestly improves prediction of poor outcome after subarachnoid hemorrhage.

Albumin-Anchored Thromboinflammatory Ratios Provide Modest Incremental Prognostic Value Beyond Clinical Severity Scores in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study.

Omer Aykanat … Lokman Bayrak

Neurocritical care · Aug 2026 · Q1 in Neurology

Background

Aneurysmal subarachnoid hemorrhage (aSAH) remains associated with substantial mortality and functional disability despite advances in neurosurgical and intensive care management.

Purpose

We aimed to evaluate the prognostic value of albumin-anchored inflammatory ratios-C-reactive protein/Albumin ratio (CAR) and D-dimer-to-Albumin Ratio (DAR)-for predicting functional outcome and in-hospital mortality in patients with aSAH.

Methods

In this retrospective multicenter cohort study, 212 adult patients with radiologically confirmed aSAH were included.

n = 212 adult

Results

adding this ratio sharpened prediction beyond age, GCS, and Hunt-Hess alone

OR by subgroup · 95% CI

More results

Poor functional outcome occurred in 88 patients (41.5%), and in-hospital mortality was observed in 36 patients (17.0%).

Both CAR and DAR were significantly higher in patients with poor outcomes (p < 0.001 for both).

More results

In multivariable analysis, DAR (adjusted OR 1.89, 95% CI 1.32-2.71, p < 0.001) and CAR (adjusted OR 1.11, 95% CI 1.04-1.18, p = 0.002) independently predicted poor functional outcome.

For mortality prediction, DAR achieved an AUC of 0.90 (95% CI 0.85-0.95).

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Conclusion · 1 of 2

Albumin-anchored inflammatory ratios, particularly DAR, were independently associated with poor functional outcome and in-hospital mortality in patients with aSAH.

Conclusion · 2 of 2

DAR provides modest incremental prognostic information beyond established clinical severity scores, supported by improvements in reclassification metrics; however, its clinical impact should be interpreted cautiously.

Albumin-Anchored Thromboinflammatory Ratios Provide Modest Incremental Prognostic Value Beyond Clinical Severity Scores in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study.

Albumin-Anchored Thromboinflammatory Ratios Provide Modest Incremental Prognostic Value Beyond Clinical Severity Scores in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study.

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