Closed loop construction of hypoglycemia risk management for high risk neonates in mother infant rooming in settings: a retrospective study with an embedded clinical decision support system.

The intelligent clinical decision support system effectively reduces neonatal hypoglycemia in rooming-in settings.

Hypoglycemia risk depends more on the specific types and combinations of high-risk factors than on their quantity alone, providing evidence for precise risk stratification.

This closed-loop, guideline-driven workflow enhances clinical standardization and patient safety. Future multicenter studies incorporating machine learning and long-term neurodevelopmental follow-up are warranted.