Radiomics-based high-resolution CT analysis for differentiating primary tumor sources of pulmonary metastases.

The PCA-reduced and regularization-optimized LR model has excellent generalization, stability and clinical interpretability in differentiating pulmonary metastases from breast and colorectal cancers.

This study preliminarily highlights the potential of LR in high-dimensional small-sample scenarios, and provides a foundational methodological reference for future large-scale multicenter diagnostic research.