Perioperative 24-Hour Lidocaine Infusion Does Not Prevent Chronic Postthoracotomy Pain: A Triple-Blinded…

Randomized trialPain physician· Jul 2026

Perioperative 24-Hour Lidocaine Infusion Does Not Prevent Chronic Postthoracotomy Pain: A Triple-Blinded Randomized Controlled Trial.

Jun Zheng, Danyang Pan, Shilang He … Lidocaine Infusion for Postthoracotomy Pain Syndrome (LIPPS) Investigators

Perioperative MedicineRandomized trialTreatmentQ1IF 3.0

Lidocaine infusion did not lower chronic pain rates after thoracoscopic surgery

Perioperative 24-Hour Lidocaine Infusion Does Not Prevent Chronic Postthoracotomy Pain: A Triple-Blinded Randomized Controlled Trial.

Jun Zheng … Lidocaine Infusion for Postthoracotomy Pain Syndrome (LIPPS) Investigators

Pain physician · Jul 2026 · Q1 in Anesthesiology

Background

Managing chronic postsurgical pain is challenging.

Purpose

To determine the effect of extending lidocaine infusion to 24 hours for treating chronic postsurgical pain in patients undergoing video-assisted thoracoscopic surgery.

Methods

A tertiary center in a university hospital.

Results

chronic pain rates were unchanged, lidocaine gave no added benefit

50%

Placebo

50%

Lidocaine

More results

There were no significant differences in acute pain scores or opioid consumption between the groups.

Dizziness was more frequent during lidocaine infusion (47% vs 14% in the placebo group, P < 0.01).

No serious adverse events were reported.

“

Conclusion

A perioperative lidocaine infusion for 24 hours added to multimodal analgesia did not prevent chronic postthoracotomy pain.

Perioperative 24-Hour Lidocaine Infusion Does Not Prevent Chronic Postthoracotomy Pain: A Triple-Blinded Randomized Controlled Trial.

Perioperative 24-Hour Lidocaine Infusion Does Not Prevent Chronic Postthoracotomy Pain: A Triple-Blinded Randomized Controlled Trial.

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