Multimodal Biomarker and Ultrasound Profiling in Women with Overactive Bladder: A Prospective Case-Control…

Case-controlInternational urogynecology journal· Aug 2026

Multimodal Biomarker and Ultrasound Profiling in Women with Overactive Bladder: A Prospective Case-Control Study.

Deniz Ozdemır, Fisun Vural, Ayse Deniz Ertürk Coskun … Hakan Beyaztas

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Incontinence & Pelvic Floor UrologyCase-controlQ2IF 2.0

Serum nerve growth factor identifies overactive bladder with near-perfect accuracy

Multimodal Biomarker and Ultrasound Profiling in Women with Overactive Bladder: A Prospective Case-Control Study.

Deniz Ozdemır … Hakan Beyaztas

International urogynecology journal · Aug 2026 · Q2 in Urology

Background

Overactive bladder (overactive bladder) remains a symptom-based diagnosis with limited objective tools for biological characterization.

Purpose

This study evaluated a multimodal profile of overactive bladder by simultaneously assessing urinary and serum biomarkers and ultrasonographic bladder parameters in women with overactive bladder.

Methods

In this prospective case-control study, 80 women were enrolled (40 overactive bladder patients [overactive bladder-V8 score ≥11], 40 age- and BMI-matched healthy controls).

n = 80 women

AUC 1.000

Results

AUC 1.000

higher serum NGF perfectly distinguishes overactive bladder from healthy bladders

n = 80 women

More results

Urinary and serum BDNF, NGF, and substance P were significantly elevated in overactive bladder (all p < 0.001), as were ultrasonographic bladder wall parameters (all p < 0.001).

Urinary substance P (ρ = 0.929) and urinary BDNF (ρ = 0.916) correlated most strongly with symptom severity.

More results

All four principal biomarkers remained independently associated with overactive bladder after adjustment for menopausal duration.

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Conclusion · 1 of 2

Women with overactive bladder exhibited a distinct multimodal biological profile characterized by neurotrophin activation, oxidative stress imbalance, and structural bladder wall changes.

Conclusion · 2 of 2

These exploratory findings require external validation in larger prospective cohorts before clinical implementation can be considered.

Multimodal Biomarker and Ultrasound Profiling in Women with Overactive Bladder: A Prospective Case-Control Study.

Multimodal Biomarker and Ultrasound Profiling in Women with Overactive Bladder: A Prospective Case-Control Study.

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