Association between ovarian sensitivity index and IVF-ET outcomes in women of advanced maternal age.
Age, not ovarian sensitivity index, independently predicts clinical pregnancy after IVF-ET.
Association between ovarian sensitivity index and IVF-ET outcomes in women of advanced maternal age.
To investigate the association between the ovarian sensitivity index (ovarian sensitivity index) and ovarian responsiveness, embryo quality, and pregnancy outcomes in women of advanced reproductive age (≥35 years) undergoing IVF-ET.
Were stratified by ovarian sensitivity index tertiles: low (≤2.174, n=353), middle (2.174- 4.103, n=351), and high (>4.103, n=351).
younger age, not ovarian sensitivity index, independently raised pregnancy odds
No significant differences were observed in infertility duration, BMI, LH, E2, T, P, or endometrial thickness on HCG day (all P>0.05).
The high ovarian sensitivity index group was younger with lower FSH and higher AMH/AFC (P<0.05), required less Gn and shorter stimulation, and yielded more oocytes, 2PN embryos, available embryos, and high-quality Day 3 embryos (P<0.05).
In univariate analysis, higher ovarian sensitivity index was associated with ovarian responsiveness, embryo quality, and clinical pregnancy rates; however, it is not independently associated with clinical pregnancy after adjustment for confounding factors, particularly age and AMH.
ovarian sensitivity index may serve as a composite indicator reflecting ovarian responsiveness and embryo quality, but should be interpreted in conjunction with age, AMH, and other relevant clinical factors.