Ethanol Sclerotherapy for Primary and Recurrent Endometrioma Improves In Vitro Fertilization Pregnancy…

Animal / preclinicalInternational journal of fertility & sterility· Jul 2026

Ethanol Sclerotherapy for Primary and Recurrent Endometrioma Improves In Vitro Fertilization Pregnancy Outcomes: A Randomized Clinical Trial.

Leila Shahsavari, Vajihe Hazari, Ashraf Aleyasin, Zeinab Samadi

Maternal-Fetal MedicineAnimal / preclinicalTreatmentQ2IF 2.5

Ethanol sclerotherapy for endometrioma more than doubled clinical pregnancy rate in IVF.

Ethanol Sclerotherapy for Primary and Recurrent Endometrioma Improves In Vitro Fertilization Pregnancy Outcomes: A Randomized Clinical Trial.

Leila Shahsavari … Zeinab Samadi

International journal of fertility & sterility · Jul 2026 · Q2 in Obstetrics & Gynecology

Background

Alcohol sclerotherapy has been shown to reduce endometrioma recurrence and improve ovarian response, including the number of retrieved oocytes and antral follicle count (antral follicle count), compared with surgical cystectomy.

Purpose

This randomized clinical trial aimed to assess the effect of ethanol sclerotherapy on assisted reproductive outcomes in women with a history of primary and recurrent endometriomas.

Methods

Were randomly assigned to the intervention group (n=40), receiving ethanol sclerotherapy, or the control group (n=40), receiving Dipherelin treatment.

n = 40

Results

ethanol treatment more than doubled clinical pregnancy compared with control

32.5%

Intervention

15%

Control

More results

The mean age of participants was 32.4 ± 4.75 years, and the mean endometrioma size was 41.45 ± 15.9 mm.

Baseline characteristics and complications rates did not differ significantly between groups.

Endometrioma recurrence was observed in 20% of patients in the intervention group within six months.

More results

Embryo quality was not significantly higher in the intervention group (P>0.05).

“

Conclusion

Ethanol sclerotherapy significantly improved clinical and chemical pregnancy rates compared to the control, suggesting that it may be a viable alternative to surgical cystectomy in selected patients, particularly those undergoing in vitro fertilization (registration number: IRCT20191206045629N1).

Ethanol Sclerotherapy for Primary and Recurrent Endometrioma Improves In Vitro Fertilization Pregnancy Outcomes: A Randomized Clinical Trial.

Ethanol Sclerotherapy for Primary and Recurrent Endometrioma Improves In Vitro Fertilization Pregnancy Outcomes: A Randomized Clinical Trial.

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