Glucocorticoid exposure and initiation of SSRIs among patients with rheumatoid arthritis: A nested case-control study in UK primary care.

The immune system might affect the development of anxiety disorders, though mechanisms remain unclear.

This nested case-control study investigates whether use of glucocorticoids, potent immunosuppressants, is associated with selective serotonin reuptake inhibitor initiation (a proxy for pharmacologically treated mental disorders, predominantly depression and/or anxiety).