Nurse-led non-pharmacological interventions for cognitive improvement in dementia patients: a systematic review and meta-analysis of randomized controlled trials.
Nurse-led interventions linked to meaningful dementia cognition gains only above 480 minutes total
Nurse-led non-pharmacological interventions for cognitive improvement in dementia patients: a systematic review and meta-analysis of randomized controlled trials.
Nurse-led non-pharmacological interventions (nurse-led non-pharmacological interventions) have gradually been recognized as a safe strategy to improve cognitive function in patients with dementia.
This study aimed to evaluate the efficacy of nurse-led non-pharmacological interventions in improving cognitive function in patients with dementia.
A systematic literature search for eligible English publications was conducted across three electronic databases (PubMed, EMBASE, and Scopus) on November 25, 2025.
Pooled analyses revealed that nurse-led non-pharmacological interventions significantly improved post-intervention cognitive function assessed immediately upon intervention termination, compared with routine nursing care.
In terms of long-term efficacy, no statistically significant cognitive improvements were observed at the 6-month follow-up after intervention completion.
Nurse-led non-pharmacological interventions effectively improve cognitive function in patients with dementia, with therapeutic benefits sustained at least until the end of the intervention.
Furthermore, the intervention effect may follow a dose-dependent pattern.
Large-sample, high-quality randomized controlled trials with standardized intervention protocols and rigorous blinding designs are warranted to further validate long-term outcomes and optimal dose thresholds, thereby generating more robust evidence for clinical dementia care.