Efficacy and safety of gepants in migraine management: a narrative review focusing on atogepant and…

ReviewJournal of oral & facial pain and headache· Jul 2026

Efficacy and safety of gepants in migraine management: a narrative review focusing on atogepant and rimegepant.

Audrey Gautier, Thomas Gicquel, Marion Mercerolle, Brendan Le Daré

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Single-dose rimegepant produced complete migraine pain relief at 2 hours in about a third of patients.

Efficacy and safety of gepants in migraine management: a narrative review focusing on atogepant and rimegepant.

Audrey Gautier … Brendan Le Daré

Journal of oral & facial pain and headache · Jul 2026 · Q3 in Neurology

Background

Gepants, oral antagonists of the calcitonin gene-related peptide (calcitonin gene-related peptide) receptor, represent a new therapeutic class in migraine management.

Purpose

This review aims to assess the efficacy and safety profile of the two gepants currently available in France: atogepant and rimegepant.

Methods

Randomized controlled trials evaluating the efficacy and/or safety of atogepant and rimegepant in adult patients with migraine were included.

Results

about a third became pain-free within 2 hours, versus 15% on placebo

Rimegepant 75mg

33%

Placebo

15%

More results

Sixteen randomized controlled trials were selected (nine evaluating atogepant and seven evaluating rimegepant).

More results

In migraine prevention, atogepant significantly reduced the mean number of monthly migraine days (-0.7 to -2.4 days vs. placebo), with an improvement in quality-of-life scores (Migraine-Specific Quality of Life questionnaire-Role Function-Restrictive domain (MSQ-RFR): +9.9 to +10.8 points).

“

Conclusion

Further real-world and long-term studies are needed to better define their place within current migraine management strategies.

Efficacy and safety of gepants in migraine management: a narrative review focusing on atogepant and rimegepant.

Efficacy and safety of gepants in migraine management: a narrative review focusing on atogepant and rimegepant.

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