Colorectal cancer screening in individuals with multiple sclerosis: A mixed-methods study.

The cohort included 63,509 pwMS and 190,527 controls (72.0% women, mean age 59.2 years).

In pwMS, cancer screening was higher in the 50-54 years (+1.5%, p < 0.001) and lower in the ⩾65 years group (-1.6% to -6.2%, p < 0.001).

Male sex (odds ratio = 0.90; 95% CI = [0.86-0.93]) and lower ecological socioeconomic status (0.81 [0.76-0.86]) were associated with lower cancer screening, while disease-modifying therapies (1.12 [1.08-1.16]) and high healthcare use with higher cancer screening.

Qualitative barriers included motor or digestive MS symptoms and feelings of disgust.