Pesticide exposure and multidomain symptom burden in Parkinson's disease: a longitudinal triangulation study.

Motor and cognition-related estimates were directionally similar in Fox Insight.

Time interaction estimates showed no consistent exposure-related differences.

Primary Cox models indicated earlier motor milestones in both cohorts and earlier sleepiness and anxiety milestones in the PPMI Online cohort.

Co-exposure to more pesticide classes was associated with worse motor function in both cohorts.