Inferior olive-selective amplitude suppression and progressive dentato-cortical decoupling during haloperidol-induced parkinsonism: a longitudinal multi-unit activity study.

We recorded multi-unit activity simultaneously from four cerebellar structures (dentate nucleus, Crus II, inferior olive, and lobulus Sim B) across three weekly sessions in male Wistar rats receiving chronic haloperidol (1.5 mg/kg/day, subcutaneous) to characterize structure-specific and longitudinally evolving cerebellar population dynamics.

During spontaneous tremor, all four structures showed elevated population amplitude alongside reduced discharge rate and irregularity, identifying temporally concentrated synchronized discharge rather than generalized hyperactivation as the mesoscopic tremor correlate.