Bioinformatic Tools to Explore the Mechanisms and the Multitarget Recognition of Huperzine A in Alzheimer's…

Animal / preclinicalCurrent drug targets· Jul 2026

Bioinformatic Tools to Explore the Mechanisms and the Multitarget Recognition of Huperzine A in Alzheimer's and Parkinson's Diseases.

Luis Antonio Ramirez-Contreras, Gabriela Camargo-Hernández, Sergio Sanchez-Enriquez … Luis Miguel Anaya Esparza

Movement DisordersAnimal / preclinicalQ2IF 3.5

Huperzine A shares 77 molecular targets common to Alzheimer's and Parkinson's disease

Bioinformatic Tools to Explore the Mechanisms and the Multitarget Recognition of Huperzine A in Alzheimer's and Parkinson's Diseases.

Luis Antonio Ramirez-Contreras … Luis Miguel Anaya Esparza

Current drug targets · Jul 2026

Background

Considering the shared physiological mechanisms between Alzheimer's disease (AD) and Parkinson's disease (PD), it is plausible that certain compounds may exert therapeutic effects on both neurological disorders.

Purpose

This study aimed to employ in silico techniques to investigate the pharmacological mechanisms of huperzine A (HA) as an alternative treatment for PD and AD.

Methods

Molecular targets of HA and genes associated with AD and PD were identified from public databases.

Results

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huperzine A hits 77 targets shared by Alzheimer's and Parkinson's disease pathways

More results

Enrichment analysis revealed that proteins from these targets were involved in biological functions, such as serotonin and amine binding.

Hub proteins (SRC, TP53, AKT1, and CASP3) were identified from the protein-protein interaction network.

More results

DISCUSSION: HA may modulate SRC, CASP3, and AKT1, suggesting a pleiotropic mechanism underlying the association between AD and PD.

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Conclusion

This study contributes to the understanding of the neuroprotective activity of HA in AD and PD. However, further in vitro and in vivo investigations are required to confirm the dual therapeutic potential of HA in the treatment of AD and PD.

Bioinformatic Tools to Explore the Mechanisms and the Multitarget Recognition of Huperzine A in Alzheimer's and Parkinson's Diseases.

Bioinformatic Tools to Explore the Mechanisms and the Multitarget Recognition of Huperzine A in Alzheimer's and Parkinson's Diseases.

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