Creatine preserves mitochondrial integrity and ameliorates early epileptiform activity and cognitive…

Animal / preclinicalBehavioural brain research· Aug 2026

Creatine preserves mitochondrial integrity and ameliorates early epileptiform activity and cognitive impairment via regulation of Na⁺,K⁺-ATPase in adolescent rats with severe traumatic brain injury.

Luiz Fernando Freire Royes, Guilherme Lago Busanello, Douglas Buchmann Godinho … Michele Rechia Fighera

Neurocritical CareAnimal / preclinicalQ2IF 3.1

Creatine cut spatial memory deficits by about half after severe brain injury in rats.

Creatine preserves mitochondrial integrity and ameliorates early epileptiform activity and cognitive impairment via regulation of Na⁺,K⁺-ATPase in adolescent rats with severe traumatic brain injury.

Luiz Fernando Freire Royes … Michele Rechia Fighera

Behavioural brain research · Aug 2026

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Results

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creatine nearly halved memory loss after brain injury

More results

In the hippocampus, the fluid percussion injury protocol did not cause overt neuronal loss-particularly of parvalbumin-positive neurons in the CA1 and CA2 regions-but it significantly reduced creatine levels and induced marked mitochondrial dysfunction.

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Conclusion

In conclusion, post-injury creatine supplementation preserves mitochondrial function, maintains Na⁺,K⁺-ATPase activity, and prevents epileptiform activity and cognitive deficits, highlighting creatine as a promising strategy to mitigate secondary injury.

Creatine preserves mitochondrial integrity and ameliorates early epileptiform activity and cognitive impairment via regulation of Na⁺,K⁺-ATPase in adolescent rats with severe traumatic brain injury.

Creatine preserves mitochondrial integrity and ameliorates early epileptiform activity and cognitive impairment via regulation of Na⁺,K⁺-ATPase in adolescent rats with severe traumatic brain injury.

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