Effectiveness of regenerative medicine for skin lightening and rejuvenation: a systematic review of…

Systematic reviewStem cell research & therapy· Sep 2025

Effectiveness of regenerative medicine for skin lightening and rejuvenation: a systematic review of extracellular vesicles and conditioned media.

Alireza Jafarzadeh, Seyed Soheil Hoseini, Elham Behrangi … Azadeh Goodarzi

DermatologySystematic reviewTreatmentQ1IF 7.4

Extracellular vesicle and conditioned media therapy associated with large skin elasticity gains

Effectiveness of regenerative medicine for skin lightening and rejuvenation: a systematic review of extracellular vesicles and conditioned media.

Alireza Jafarzadeh … Azadeh Goodarzi

Stem cell research & therapy · Sep 2025 · Q1 in General Medicine

Purpose

This study aims to evaluate and summarize the efficacy and safety of extracellular vesicles (extracellular vesicles) and conditioned media (conditioned media) as emerging therapeutic approaches in regenerative medicine for skin rejuvenation and lightening.

Methods

A systematic search was conducted up to September 19, 2024, using the PubMed, Scopus, and Web of Science databases.

n = 624 patients

Results

elasticity rose after treatment, more spring and firmness in the skin

27.07%

Elasticity increase

10%

Wrinkle reduction

20%

Hydration enhancement

More results

Among these, 21% investigated the effects of extracellular vesicles, while 78% focused on CMs.

The most commonly assessed skin parameters included wrinkles, pigmentation, spots, elasticity, and hydration.

Various application methods were used, including topical administration, microneedling, and fractional laser therapy.

More results

No serious adverse effects were reported, with only transient minor reactions such as erythema observed.

“

Conclusion · 1 of 2

Extracellular vesicles and CMs appear to be safe and potentially effective for skin rejuvenation and lightening.

Conclusion · 2 of 2

However, further high-quality studies are required to confirm long-term safety, investigate variations in efficacy based on cell sources, and optimize application techniques for clinical use.

Effectiveness of regenerative medicine for skin lightening and rejuvenation: a systematic review of extracellular vesicles and conditioned media.

Effectiveness of regenerative medicine for skin lightening and rejuvenation: a systematic review of extracellular vesicles and conditioned media.

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