Efficacy and Safety Evaluation of Microneedling Combined with Tranexamic Acid-Arbutin Liquid Excipients in…

Cohort studyClinical, cosmetic and investigational dermatology· 2025

Efficacy and Safety Evaluation of Microneedling Combined with Tranexamic Acid-Arbutin Liquid Excipients in the Treatment of Melasma: A Retrospective Study.

Mingli Zhang, Jincheng Ke, Yunhe Jiao, Li Ma

Cosmetic & AestheticCohort studyTreatmentQ2IF 2.5

Melasma severity score fell 37.6% after microneedling with tranexamic acid-arbutin treatment.

Efficacy and Safety Evaluation of Microneedling Combined with Tranexamic Acid-Arbutin Liquid Excipients in the Treatment of Melasma: A Retrospective Study.

Mingli Zhang … Li Ma

Clinical, cosmetic and investigational dermatology · 2025 · Q2 in Dermatology

Background

The condition of melasma presents a complex pigmented skin disorder, characterized by increased production of melanin in the dermis.

Methods

A single-center retrospective dermatology study (Jan 2022-Jun 2023, n=27) evaluated microneedling plus tranexamic acid-arbutin solution for melasma.

n = 27 patients

Results

melasma severity dropped sharply after treatment

Before treatment

5.426mMASI

After treatment

3.387mMASI

More results

Before treatment, the average mMASI score of 27 patients with melasma was 5.426±2.128.

In terms of the PGA score, 20 patients achieved a score of 3 or higher (overall rate: 74.07%).

The observed adverse reactions mainly include temporary erythema, burning sensation, petechiae (or/and ecchymosis), and skin dryness.

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Conclusion · 1 of 2

Microneedling combined with tranexamic acid-arbutin liquid adjuvant treatment for melasma is feasible and well-tolerated.

Conclusion · 2 of 2

Its side effects are relatively few, but it is still recommended to appropriately adjust the treatment intervals, intensity, and density, or combine it with other methods to enhance efficacy.

Efficacy and Safety Evaluation of Microneedling Combined with Tranexamic Acid-Arbutin Liquid Excipients in the Treatment of Melasma: A Retrospective Study.

Efficacy and Safety Evaluation of Microneedling Combined with Tranexamic Acid-Arbutin Liquid Excipients in the Treatment of Melasma: A Retrospective Study.

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