VYC-17.5L is Safe and Effective in Improving Skin Quality and Volume Deficit of Hands: Results From an 18-Month Open-Label Study.

Seventy-five participants (94.7% female; mean age, 53.89 years) had both hands injected with VYC-17.5L (median, 2.0 mL/hand), and 60.0% of hands received touch-up (median, 1.0 mL/hand).

Most hands (≥ 85%) improved on investigator- and participant-GAIS through month 12.

Significant skin quality improvements persisted to 12 months.

Twenty-two (29.3%) participants experienced treatment-related adverse events; most were mild or moderate in severity with a mean duration of 45.1 days, and none led to study discontinuation.