Efficacy and Safety of Amino Acid-Enriched Hyaluronic Acid in Facial Rejuvenation: A Systematic Review and Meta-Analysis.

Global aesthetic improvement demonstrated a marked enhancement at 3 months (MD = 3.13; 95% CI = 1.94-4.33; p < 0.00001).

Dermal thickness significantly increased post-treatment (MD = -0.42 mm; 95% CI = -0.55 to -0.30; p < 0.00001).

Cell viability improved significantly (MD = -24.00; 95% CI = -25.16 to -22.84; p < 0.00001).

There was a statistically significant difference in adverse events (RR = 5.20; 95% CI = 0.53-50.77; p = 0.16).