Advanced Regenerative Drainage and Immunomodulatory Protocol for Dermal Filler-Induced Skin Necrosis: A…

StudyJournal of cosmetic dermatology· Apr 2026

Advanced Regenerative Drainage and Immunomodulatory Protocol for Dermal Filler-Induced Skin Necrosis: A Prospective Clinical Case Series.

Macarena Olivares, Diego Araya, Eloisa Forero … Victor Mercado

Cosmetic & AestheticStudyTreatmentQ1IF 3.1

95% of patients treated with ARDIP had complete scar-free skin recovery

Advanced Regenerative Drainage and Immunomodulatory Protocol for Dermal Filler-Induced Skin Necrosis: A Prospective Clinical Case Series.

Macarena Olivares … Victor Mercado

Journal of cosmetic dermatology · Apr 2026 · Q1 in Dermatology

Background

The widespread use of hyaluronic acid (hyaluronic acid) dermal fillers has been accompanied by an increase in vascular complications, including ischemia and cutaneous necrosis.

Purpose

To evaluate the clinical outcomes of the Advanced Regenerative and Immunomodulatory Drainage Protocol (ARDIP), a multimodal therapeutic approach designed to restore tissue perfusion, reduce inflammatory burden, and promote regenerative healing in patients with facial skin necrosis secondary to hyaluronic acid dermal fillers.

Methods

A prospective, non-randomized interventional case series was conducted including 20 patients presenting with vascular occlusion (vascular occlusion) and cutaneous necrosis following hyaluronic acid injections.

n = 20 patients

95%

Results

95%

nearly all patients healed with no lasting scars

n = 20 patients

More results

All patients completed treatment and follow-up.

Mean healing time was 15 ± 2.6 days, with faster recovery in early stages.

The mean Global Aesthetic Improvement Scale score was 1.05 ± 0.22, indicating exceptional aesthetic improvement.

No systemic or local adverse events were observed.

“

Conclusion

ARDIP appears to be a safe and effective multimodal strategy for the management of filler-induced skin necrosis, addressing both mechanical vascular obstruction and the associated inflammatory cascade.

Advanced Regenerative Drainage and Immunomodulatory Protocol for Dermal Filler-Induced Skin Necrosis: A Prospective Clinical Case Series.

Advanced Regenerative Drainage and Immunomodulatory Protocol for Dermal Filler-Induced Skin Necrosis: A Prospective Clinical Case Series.

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