Long-Term Efficacy and Safety of Oleogel-S10 (Birch Triterpenes) for Pediatric Patients With Epidermolysis…

Randomized trialPediatric dermatology· May 2026

Long-Term Efficacy and Safety of Oleogel-S10 (Birch Triterpenes) for Pediatric Patients With Epidermolysis Bullosa.

Eli Sprecher, Mauricio Torres-Pradilla, Maria Florencia Fernandez … EASE Study Group

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Pediatric DermatologyRandomized trialTreatmentQ2IF 1.1

Oleogel-S10 nearly doubled early complete wound closure in pediatric epidermolysis bullosa

Long-Term Efficacy and Safety of Oleogel-S10 (Birch Triterpenes) for Pediatric Patients With Epidermolysis Bullosa.

Eli Sprecher … EASE Study Group

Pediatric dermatology · May 2026 · Q2 in Dermatology

Background

Pediatric patients with epidermolysis bullosa (epidermolysis bullosa) experience lifelong complications, and wound healing is an important treatment goal.

Purpose

This prespecified subgroup analysis evaluated the long-term efficacy and safety of Oleogel-S10 in patients aged < 18 years from EASE.

Methods

EASE comprised a 90-day double-blind phase (DBP) and 24-month open-label phase (open-label phase).

n = 74

Results

wounds fully closed within 45 days more often with Oleogel-S10

RR 1.70 (95% CI 1.11 to 2.60)

null 1

1.11

2.60

CI excludes the null - significant

More results

Mean absolute body surface area percentage scores were 12.5% at DBP baseline and 5.3% at open-label phase Month 24 for the Oleogel-S10 group.

Significantly more patients treated with Oleogel-S10 (38%) no longer required daily dressing changes versus control gel (9%) at DBP Day 90.

More results

Similar proportions of patients experienced adverse events in the Oleogel-S10 and control gel groups in the DBP, with most mild or moderate.

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Conclusion

These analyses of pediatric patients demonstrated accelerated wound healing, reduced frequency of dressing changes, and sustained reduction in wound burden up to 27 months. Long-term safety was consistent with the overall EASE population.

Long-Term Efficacy and Safety of Oleogel-S10 (Birch Triterpenes) for Pediatric Patients With Epidermolysis Bullosa.

Long-Term Efficacy and Safety of Oleogel-S10 (Birch Triterpenes) for Pediatric Patients With Epidermolysis Bullosa.

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