A Bidirectional Mendelian Randomization Study of Androgenetic Alopecia and Obesity.

StudyClinical, cosmetic and investigational dermatology· 2026

A Bidirectional Mendelian Randomization Study of Androgenetic Alopecia and Obesity.

Hong Lin, Yuanjun Liu

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Hair & NailStudyPrognosisQ2IF 2.5

Obesity shows no causal effect on androgenetic alopecia risk

A Bidirectional Mendelian Randomization Study of Androgenetic Alopecia and Obesity.

Hong Lin, Yuanjun Liu

Clinical, cosmetic and investigational dermatology · 2026 · Q2 in Dermatology

Background

Androgenetic alopecia (androgenetic alopecia) is a prevalent hereditary hair follicle disorder.

Methods

Bidirectional two-sample Mendelian randomization (mendelian randomization) design was performed to explore causal links between obesity and androgenetic alopecia.

Results

obesity does not raise or lower alopecia risk

OR 1.01 (95% CI 0.98 to 1.04)

null 1

0.98

1.04

CI crosses the null - not significant

More results

Subsequent pleiotropy testing and leave-one-out sensitivity analyses yielded concordant outcomes without detectable horizontal pleiotropic bias.

“

Conclusion · 1 of 2

This mendelian randomization analysis excludes bidirectional causal associations between obesity and androgenetic alopecia.

Conclusion · 2 of 2

Previously observed epidemiological correlations between the two phenotypes are plausibly driven by confounding variables rather than direct causation, providing novel genetic epidemiological evidence for androgenetic alopecia pathogenic exploration.

A Bidirectional Mendelian Randomization Study of Androgenetic Alopecia and Obesity.

A Bidirectional Mendelian Randomization Study of Androgenetic Alopecia and Obesity.

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