Dihalogenated indoles with antimicrobial activity against C. acnes and polymicrobial biofilms.

Animal / preclinicalMicrobial pathogenesis· Sep 2026

Dihalogenated indoles with antimicrobial activity against C. acnes and polymicrobial biofilms.

Sacheera Angulmaduwa, Ratupaskatiye G G Roshan Pradeep, Yong-Guy Kim … Jintae Lee

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Acne & RosaceaAnimal / preclinicalQ2IF 4.4

Dihalogenated indole compound inhibits C. acnes growth at a low concentration.

Dihalogenated indoles with antimicrobial activity against C. acnes and polymicrobial biofilms.

Sacheera Angulmaduwa … Jintae Lee

Microbial pathogenesis · Sep 2026

Background

Acne vulgaris is a chronic inflammatory skin disorder in which Cutibacterium acnes contributes to disease persistence through biofilm formation, lipid metabolism, and production of inflammatory metabolites within the pilosebaceous unit.

Methods

In this study, we evaluated a panel of halogenated indole derivatives and identified 6-bromo-4-iodoindole as a potent inhibitor of C. acnes growth and biofilm formation.

20 μg/mL

Results

20 μg/mL

Minimum concentration of compound needed to stop C. acnes growth; lower means more potent.

More results

Docking simulations suggested that 6-bromo-4-iodoindole occupies the catalytic pocket of C. acnes triacylglycerol lipase, providing a structural basis for the observed suppression of lipase-dependent phenotypes.

In silico pharmacokinetic analyses further indicated physicochemical properties compatible with localized topical delivery.

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Conclusion · 1 of 2

Together, these findings demonstrate that a dihalogenated indole reduces lipase-associated virulence related phenotypes in C.

Conclusion · 2 of 2

acnes and suppresses biofilm formation in skin-relevant environments, supporting further investigation of this scaffold as a therapeutic strategy targeting acne-associated microbial physiology.

Dihalogenated indoles with antimicrobial activity against C. acnes and polymicrobial biofilms.

Dihalogenated indoles with antimicrobial activity against C. acnes and polymicrobial biofilms.

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