Clinical outcomes associated with a digital standardized skin care regimen in acne-rosacea comorbidity: A…

Cohort studyJournal of the American Academy of Dermatology· Jul 2026

Clinical outcomes associated with a digital standardized skin care regimen in acne-rosacea comorbidity: A real-world longitudinal study with cross-lagged and mediation analyses.

Yuxin Qing, Kaijing Zhang, Bingyang Xu … Jiawen Wu

Acne & RosaceaCohort studyClinical practiceQ1IF 2.5

Digital skin care regimen linked to higher skin clearance in acne-rosacea patients

Clinical outcomes associated with a digital standardized skin care regimen in acne-rosacea comorbidity: A real-world longitudinal study with cross-lagged and mediation analyses.

Yuxin Qing … Jiawen Wu

Journal of the American Academy of Dermatology · Jul 2026 · Q1 in Dermatology

Background

Co-occurring acne and rosacea is challenging.

Purpose

To evaluate associations between SSCG participation and outcomes, the clinical-barrier temporal sequence, transepidermal water loss (transepidermal water loss) mediation, and communication frequency.

Methods

Single-center retrospective cohort with verified dual diagnosis.

Results

59% higher rate of clear or almost-clear skin at 12 weeks with the regimen

RR 1.59 (95% CI 1.31 to 1.92)

null 1

1.31

1.92

CI excludes the null - significant

More results

Week-6 IGA predicted week-12 transepidermal water loss reduction; the reverse path was nonsignificant.

Transepidermal water loss mediated 12.4% of the estimated association.

Communication frequency showed no dose-response.

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Conclusion

In this cohort, SSCG participation was associated with higher clearance and lower relapse. Findings are associative and hypothesis-generating.

Clinical outcomes associated with a digital standardized skin care regimen in acne-rosacea comorbidity: A real-world longitudinal study with cross-lagged and mediation analyses.

Clinical outcomes associated with a digital standardized skin care regimen in acne-rosacea comorbidity: A real-world longitudinal study with cross-lagged and mediation analyses.

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