Long-term risk of incident psoriasis in patients with irritable bowel syndrome: a large-scale prospective cohort study.
Irritable bowel syndrome linked to 35% higher risk of developing psoriasis
Long-term risk of incident psoriasis in patients with irritable bowel syndrome: a large-scale prospective cohort study.
While irritable bowel syndrome (irritable bowel syndrome) and psoriasis share some pathophysiological features, it remains unclear whether they are associated with one another.
Therefore, we aimed to investigate the long-term risk of incident psoriasis in a large prospective cohort of patients with irritable bowel syndrome.
We retrieved data on 437,170 participants from the UK Biobank without psoriasis at baseline.
Irritable bowel syndrome raises later psoriasis risk by over a third
We identified 21,748 (5.0%) irritable bowel syndrome patients among the 437,170 participants.
0.69% (95% CI = 0.66-0.72) in the non-irritable bowel syndrome group.
In subgroup analyses, a higher psoriasis risk associated with irritable bowel syndrome was generally observed across age, sex, Townsend deprivation index, smoking status, non-steroidal anti-inflammatory drug use, C-reactive protein, and polygenic risk score of psoriasis subgroups.
The irritable bowel syndrome patients in our sample had an increased long-term risk of incident psoriasis.
This finding highlights the importance of monitoring psoriasis in irritable bowel syndrome patients and suggests a potential shared pathophysiological mechanism between the two conditions which may inform future preventive and therapeutic strategies.