Pre-Treatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Prognostic Biomarkers for Sentinel Lymph Node Positivity and Recurrence-Free Survival in Primary Cutaneous Melanoma: An Exploratory Single-Centre Retrospective Cohort Study.

In this exploratory, single-center retrospective cohort, pre-treatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were inexpensive, widely available biomarkers that were associated with prognostically relevant melanoma features and outcomes.

These hypothesis-generating findings suggest that inflammatory ratios could complement conventional histopathologic predictors, but they were derived and tested within a single small cohort without independent validation and require confirmation in larger, prospective, multi-center studies before any clinical application.