Primary care diagnosed multimorbidity and risk of venous thromboembolism in Sweden.

Cohort studyInternational journal of cardiology. Cardiovascular risk and prevention· Jun 2026

Primary care diagnosed multimorbidity and risk of venous thromboembolism in Sweden.

Jonatan Ahrén, MirNabi Pirouzifard, Björn Holmquist … Bengt Zöller

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Chronic Disease ManagementCohort studyPrognosisQ2IF 2.8

Primary care-diagnosed multimorbidity is associated with higher venous thromboembolism risk

Primary care diagnosed multimorbidity and risk of venous thromboembolism in Sweden.

Jonatan Ahrén … Bengt Zöller

International journal of cardiology · Jun 2026 · Q2 in General Medicine

Background

Multimorbidity, the co-occurrence of two or more non-communicable diseases (non-communicable diseases), is common and has been linked to venous thromboembolism (venous thromboembolism).

Purpose

We aimed to examine this association.

Methods

Multimorbidity was defined using Swedish primary-care data.

n = 8,170,329 individuals

Results

multimorbidity raised venous thromboembolism risk by about a third

subHR 1.36 (95% CI 1.34 to 1.39)

CI excludes the null - significant

More results

Among 8,170,329 included individuals, 2,183,236 (26.72%) had primary care-diagnosed multimorbidity.

A dose-response association was observed, a subHR of 1.62 (95%CI 1.57-1.67) for individuals with ≥5 non-communicable diseases.

There were significant interactions between multimorbidity and sex and country of birth.

More results

Seven of nine multimorbidity clusters were associated with increased venous thromboembolism risk.

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Conclusion · 1 of 2

Primary care-diagnosed multimorbidity is an independent, dose-dependent risk factor for venous thromboembolism.

Conclusion · 2 of 2

The association between several disease-clusters and venous thromboembolism suggests potential value in cluster-based risk prediction.

Primary care diagnosed multimorbidity and risk of venous thromboembolism in Sweden.

Primary care diagnosed multimorbidity and risk of venous thromboembolism in Sweden.

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