Opioid Therapy Discontinuation in General Practice: Associations with Adjunct Therapies and Somatoform Pain Disorders.

These findings are consistent with current guideline recommendations emphasizing the use of adjunct therapies in chronic non-cancer pain management in general practice.

Caution is warranted when prescribing opioids to patients with somatoform pain disorders or concurrent substance use disorders.

Further research with longer observation periods is needed to confirm these associations and better understand their underlying mechanisms.