Scale-up evaluation results of a multi-level approach using mailed immunochemical test (FIT) and patient navigation to increase colorectal cancer screening rates in rural clinic settings.

Participation in multifaceted scale-up activities increased organizational knowledge and engagement in colorectal cancer screening patient outreach within rural, low-resourced clinic settings.

These activities also supported the refinement of existing colorectal cancer screening programs through the adoption and modification of outreach strategies.

These findings can inform future efforts to optimize scale-up approaches for colorectal cancer screening and other complex interventions in rural, low-resourced healthcare settings.