Complicated Acute Rhinosinusitis in Cystic Fibrosis: National Inpatient Pediatric Analysis.
Children with cystic fibrosis have far lower odds of orbital complications from rhinosinusitis
Complicated Acute Rhinosinusitis in Cystic Fibrosis: National Inpatient Pediatric Analysis.
No prior national-level hospital admission analysis has compared acute rhinosinusitis (acute rhinosinusitis) outcomes between cystic fibrosis (cystic fibrosis) and non-cystic fibrosis pediatric patients, leaving clinicians without population-level data to contextualize hospitalization burden and complication rates in this group.
We aimed to compare the complication risks and healthcare utilization between patients with cystic fibrosis versus without cystic fibrosis in children hospitalized with acute rhinosinusitis.
The study examined inpatient admissions for pediatric acute rhinosinusitis patients with or without cystic fibrosis in 2003-2019 using the Kids' Inpatient Database (KID), Healthcare Cost and Utilization Project (Healthcare Cost and Utilization Project), Agency for Healthcare Research and Quality.
cystic fibrosis sharply lowers the odds of orbital spread
Of the weighted 41,148 patients with acute rhinosinusitis, 1.5% had cystic fibrosis (n = 632).
Cystic fibrosis patients also had longer hospital stays (8 vs 3 days, P < .001) and higher hospital charges ($43,918 vs $11,129, P < .001) compared to non-cystic fibrosis patients.
Children with concurrent cystic fibrosis and acute rhinosinusitis experience greater overall disease burden, reflected in prolonged hospitalization, higher healthcare costs, and higher rates of sinus surgeries.
However, cystic fibrosis patients appear less prone to orbital complications.