Impact of COPD on Outcomes After Pulmonary Metastasectomy: A Propensity-Score Matched Analysis.
Chronic obstructive pulmonary disease associated with higher persistent air leak rates after pulmonary metastasectomy
Impact of COPD on Outcomes After Pulmonary Metastasectomy: A Propensity-Score Matched Analysis.
Pulmonary metastasectomy (pulmonary metastasectomy) is an established component of multimodal oncological treatment, but its perioperative safety and long-term outcomes in patients with chronic obstructive pulmonary disease (chronic obstructive pulmonary disease) remain insufficiently defined.
We aimed to evaluate the impact of chronic obstructive pulmonary disease on perioperative morbidity, mortality and long-term survival after pulmonary metastasectomy.
We retrospectively analysed 692 patients who underwent pulmonary metastasectomy with curative intent.
Chronic obstructive pulmonary disease raises persistent air leak risk after surgery
Among 9684 patients, 692 (7.1%) patients underwent pulmonary metastasectomy, of whom 171 (24.7%) had chronic obstructive pulmonary disease.
Overall morbidity and 30-day mortality, however, did not differ.
Independent predictors of worse survival were preoperative systemic therapy (HR 2.18), repeat metastasectomy (HR 1.60) and increasing age (HR 1.02 per year).
After propensity matching, survival remained comparable (HR 1.05, p = 0.835).
Among carefully selected patients, chronic obstructive pulmonary disease was not associated with increased mortality or reduced survival after pulmonary metastasectomy, although persistent air leak was significantly more frequent.
chronic obstructive pulmonary disease alone should not, by itself, be considered a contraindication to curative-intent surgery in appropriately selected patients, and these findings should not be generalized to patients with severe or end-stage chronic obstructive pulmonary disease.