Glomerular hyperfiltration in dipstick-negative type 2 diabetes mellitus: a novel determinant of kidney…

Cohort studyKidney research and clinical practice· Jul 2026

Glomerular hyperfiltration in dipstick-negative type 2 diabetes mellitus: a novel determinant of kidney function decline in type 2 diabetes mellitus.

Dughyun Choi, Samel Park, Dong-Sub Kim … Eun Young Lee

NephrologyCohort studyPrognosisQ1IF 2.6

Type 2 diabetes linked to 57% higher risk of kidney function decline despite normal baseline eGFR

Glomerular hyperfiltration in dipstick-negative type 2 diabetes mellitus: a novel determinant of kidney function decline in type 2 diabetes mellitus.

Dughyun Choi … Eun Young Lee

Kidney research and clinical practice · Jul 2026

Background

The independent impact of type 2 diabetes mellitus (T2DM) on kidney outcomes beyond albuminuria remains unclear.

Methods

Data from the National Health Insurance Service-National Sample Cohort of Korea (2009-2015) were analyzed.

n = 77,267 individuals

Results

T2DM raises kidney decline risk even with normal starting kidney function

HR 1.57 (95% CI 1.28 to 1.92)

null 1

1.28

1.92

CI excludes the null - significant

More results

Among 77,267 individuals with normal kidney function without albuminuria, patients with T2DM (n = 11,957) showed significantly steeper annual decline in eGFR than non-T2DM individuals (-0.113 mL/min per 1.73 m2 per year; 95% confidence interval [CI], -0.222 to -0.003).

More results

This association was strongest in individuals with glomerular hyperfiltration and longer T2DM duration (≥6 years).

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Conclusion

Normal kidney function T2DM was associated with accelerated kidney function decline and a 1.5-fold increased risk of adverse kidney outcomes compared with normal kidney function non-T2DM, particularly in individuals with glomerular hyperfiltration and longer duration.

Glomerular hyperfiltration in dipstick-negative type 2 diabetes mellitus: a novel determinant of kidney function decline in type 2 diabetes mellitus.

Glomerular hyperfiltration in dipstick-negative type 2 diabetes mellitus: a novel determinant of kidney function decline in type 2 diabetes mellitus.

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