Multi-Institutional Development and Validation of a Nomogram Based on New Microvascular Ultrasound…

Cohort studyJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine· Aug 2026

Multi-Institutional Development and Validation of a Nomogram Based on New Microvascular Ultrasound Techniques to Predict the Severity of Renal Fibrosis in Chronic Kidney Disease.

Yao Zhang, Jingchen Liang, Xingyue Huang … Qing Zhou

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NephrologyCohort studyDiagnosisQ2IF 2.5

Ultrasound-based nomogram predicts moderate-to-severe renal fibrosis in chronic kidney disease

Multi-Institutional Development and Validation of a Nomogram Based on New Microvascular Ultrasound Techniques to Predict the Severity of Renal Fibrosis in Chronic Kidney Disease.

Yao Zhang … Qing Zhou

Journal of ultrasound in medicine · Aug 2026 · Q2 in General Medicine

Purpose

To develop and validate a nomogram integrating ultrasound microvascular imaging (super-resolution ultrasound [SRUS], superb microvascular imaging [SMI]), resistive index (resistive index), and clinical features for the non-invasive assessment of renal fibrosis severity in chronic kidney disease (chronic kidney disease).

Methods

A total of 208 chronic kidney disease patients (141 in the training cohort and 67 in the external validation cohort) were included in the study.

n = 208 CKD patients

Results

higher score means better prediction of significant kidney scarring

AUC 0.94 (95% CI 0.91 to 0.98)

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0.91

0.98

CI excludes the null - significant

More results

The nomogram, incorporating SRUS, SMI, resistive index, hypertension, blood urea nitrogen (blood urea nitrogen), and estimated glomerular filtration rate (eGFR), showed good predictive performance.

More results

Calibration analyses showed acceptable agreement between predicted and observed probabilities, with calibration intercepts/slopes of 0.003/1.002 in the training cohort and -0.296/0.767 in the external validation cohort.

“

Conclusion

This nomogram may provide a non-invasive approach for assessing renal fibrosis severity and supporting risk stratification in patients with chronic kidney disease.

Multi-Institutional Development and Validation of a Nomogram Based on New Microvascular Ultrasound Techniques to Predict the Severity of Renal Fibrosis in Chronic Kidney Disease.

Multi-Institutional Development and Validation of a Nomogram Based on New Microvascular Ultrasound Techniques to Predict the Severity of Renal Fibrosis in Chronic Kidney Disease.

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