Body Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.
Adverse muscle composition is far more common in heart failure than in controls
Body Composition in Heart Failure: A Magnetic Resonance Imaging and Dual X-Ray Absorptiometry Assessment in the UK Biobank Study.
Metabolic and musculoskeletal abnormalities in patients with heart failure (heart failure) may not be fully captured by body mass index.
Body composition was studied in participants with heart failure and matched control subjects in the UK Biobank Imaging Study, and findings were compared among those with heart failure with reduced ejection fraction, heart failure with mildly reduced ejection fraction, and heart failure with preserved ejection fraction.
With heart failure and available ejection fraction (n = 185) were matched 1:5 to age-, sex-, and body mass index-matched control subjects (n = 925).
Adverse muscle composition affects nearly 1 in 3 with heart failure, about 1 in 6 in controls
Despite the muscle derangements identified by magnetic resonance imaging assessment, the prevalence of sarcopenia diagnosed using combined grip strength and dual-energy x-ray absorptiometry-derived lean mass parameters varied considerably depending on the criteria applied.
Among heart failure subtypes, heart failure with mildly reduced ejection fraction showed the highest visceral adipose tissue and lowest muscle volume, heart failure with preserved ejection fraction had greater fat and muscle fat infiltration, and heart failure with reduced ejection fraction had the greatest prevalence of adverse muscle composition and the weakest grip strength.
Participants with heart failure showed higher visceral adipose tissue and adverse muscle changes, with weaker grip strength.
Sarcopenia prevalence varied substantially across definitions, reflecting substantial variability and discrepancies among current sarcopenia definitions and criteria.
Traditional anthropometric indexes underestimate the burden of body composition derangements in heart failure.