U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure.
Enlarged left ventricles were linked to higher mortality risk in heart failure patients.
U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure.
IMPORTANCE: Left ventricular structural assessment is fundamental in heart failure (heart failure).
To investigate the association between left ventricular dimension and mortality risk within a large, nationwide cohort with heart failure.
DESIGN, SETTING, AND PARTICIPANTS: This was a nationwide cohort study using data from the Chinese Cardiovascular Association Database-Heart Failure Center Registry.
a larger left ventricle raised the risk of death
A significant U-shaped association was found between LV end-diastolic diameter and both all-cause and cardiovascular mortality (P for nonlinearity <.001).
Sex-specific optimal LV end-diastolic diameter thresholds were identified (47 mm for male patients, 43 mm for female patients), with each 1-mm deviation associated with a significant increase in mortality risk.
This large-scale study established that a U-shaped association exists between left ventricle end-diastolic diameter and mortality in heart failure, suggesting that both abnormally small and abnormally large ventricles signify high risk, likely through distinct mechanisms.
These findings support the integration of left ventricle size assessment into routine risk stratification to guide personalized management.