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Cohort studyEinstein (Sao Paulo, Brazil) · 2026

Evaluation of anticoagulation quality in patients with primary antiphospholipid syndrome at a tertiary hospital.

Renata Lys Pinheiro de Mello, Maria Eugênia Teixeira Bicalho, Gustavo Guimarães Moreira Balbi … Danieli Castro Oliveira de Andrade

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Internal MedicineCohort study

Only 34.4% of primary antiphospholipid syndrome patients had adequate anticoagulation control

Evaluation of anticoagulation quality in patients with primary antiphospholipid syndrome at a tertiary hospital.

Renata Lys Pinheiro de Mello … Danieli Castro Oliveira de Andrade

Einstein (Sao Paulo, Brazil) · 2026

Purpose

This study aimed to evaluate the quality of anticoagulation control in patients with primary antiphospholipid syndrome, using time in therapeutic range.

Methods

Anticoagulation quality was assessed in a retrospective study including patients with primary Antiphospholipid Syndrome.

n = 93 patients

Results

34.4%

just over a third stayed safely anticoagulated, most were not

n = 93 patients

More results

Among these, 32 patients (74.4 achieved time in therapeutic range ≥60%, with a median time in therapeutic range of 89.3%.

However, 61 patients (65.6%) had insufficient follow-up, resulting in an incalculable time in therapeutic range.

More results

No significant differences were observed between patients with good and poor anticoagulation control regarding demographic or clinical variables.

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Conclusion · 1 of 2

Our findings indicates that only 34.4% of patients with primary antiphospholipid syndrome achieved adequate anticoagulation control and inadequate follow-up remains a major barrier.

Conclusion · 2 of 2

Further studies are needed to identify factors contributing to suboptimal time in therapeutic range and to improve anticoagulation management in this high-risk population.

Post

Evaluation of anticoagulation quality in patients with primary antiphospholipid syndrome at a tertiary hospital.

Only 34.4% of primary antiphospholipid syndrome patients had adequate anticoagulation control

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