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New research · Internal Medicine
International journal of medical informatics · 3h
Cohort studyInternational journal of medical informatics · 2026

Development and internal-external validation of a nomogram model for lower extremity deep vein thrombosis in patients after ruptured intracranial aneurysm surgery based on dynamic D-dimer trajectory.

Jiansong Yu, Ting Guo, Wei Hu … Yongpo Jiang
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Internal MedicineCohort study

Nomogram using D-dimer trajectory predicted deep vein thrombosis after aneurysm surgery in external validation

Development and internal-external validation of a nomogram model for lower extremity deep vein thrombosis in patients after ruptured intracranial aneurysm surgery based on dynamic D-dimer trajectory.

Jiansong Yu … Yongpo Jiang
International journal of medical informatics · 2026
Purpose

This study aimed to develop and validate a nomogram model for predicting lower extremity deep venous thrombosis (lower extremity deep venous thrombosis) after ruptured intracranial aneurysm (ruptured intracranial aneurysm) surgery based on dynamic D-dimer trajectory, to support accurate identification of high-risk populations and individualized thrombosis prevention in clinical practice.

Methods

Were split into training and test sets at an 8:2 ratio; an independent external validation set included patients from another hospital.

n = 294,
Results

correctly separates future clot cases from those without most of the time

Training set
0.76AUC
Test set
0.81AUC
External validation
0.75AUC
More results

Four D-dimer trajectory subgroups were identified by Gaussian Mixture Model.

LASSO regression screened age, surgical type, GCS score and D-dimer trajectory as key predictors.

“
Conclusion

This validated nomogram integrating four core factors can accurately predict postoperative lower extremity deep venous thrombosis risk in ruptured intracranial aneurysm patients.

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