Continuation of direct oral anticoagulants versus warfarin during critical illness: bleeding and clinical outcomes in a multicenter ICU cohort.

The comparative safety of continuing direct oral anticoagulants versus warfarin during critical illness remains uncertain.

The primary outcome was major bleeding during the index hospitalization.

In the multivariable analysis, there was no statistically significant difference in major bleeding events, (aOR 1.34, 95% CI 0.89-2.02; p = 0.161) between the direct oral anticoagulants and warfarin groups, respectively.