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Cohort studyNeurotrauma reports · 2026

Perioperative Discontinuation of Antiplatelet and Anticoagulation Therapy in Chronic Subdural Hematoma: Impact on in-Hospital Mortality, Functional Outcome, and Recurrence.

Schahin Salmanian, Jan Rodemerk, Sali Al-Rubaiey … Mehdi Chihi

Internal MedicineCohort study

Prior aspirin use was associated with lower chronic subdural hematoma recurrence after surgery.

Perioperative Discontinuation of Antiplatelet and Anticoagulation Therapy in Chronic Subdural Hematoma: Impact on in-Hospital Mortality, Functional Outcome, and Recurrence.

Schahin Salmanian … Mehdi Chihi

Neurotrauma reports · 2026

Purpose

The purpose of this study was to evaluate the effect of perioperative discontinuation of antiplatelet and anticoagulation therapy (anticoagulation therapy) on in-hospital mortality, functional outcome, and recurrence in patients with chronic subdural hematoma (chronic subdural hematoma) with prior anticoagulation therapy use, compared to patients without anticoagulation therapy.

Methods

We retrospectively analyzed data from patients with symptomatic chronic subdural hematoma who underwent surgery in our department between June 2012 and December 2023.

Results

aspirin users had roughly half the recurrence odds of non-users

aOR 0.50 (95% CI 0.29 to 0.88)

null 1

0.29

0.88

CI excludes the null - significant

More results

Prior anticoagulation therapy was discontinued at hospital admission and reinitiated 3 weeks postoperatively if chronic subdural hematoma resolution was complete.

More results

Among 852 surgically treated chronic subdural hematoma patients (mean age 75.2 years; female-to-male ratio 1:2.1), univariate analysis revealed that prior anticoagulation therapy use was significantly associated with higher in-hospital mortality ( p = 0.043) and poor functional outcome ( p < 0.001), but not with recurrence ( p = 0.434).

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Conclusion

Intriguingly, prior aspirin therapy was associated with reduced recurrence, suggesting a potential protective role.

Post

Perioperative Discontinuation of Antiplatelet and Anticoagulation Therapy in Chronic Subdural Hematoma: Impact on in-Hospital Mortality, Functional Outcome, and Recurrence.

Prior aspirin use was associated with lower chronic subdural hematoma recurrence after surgery.

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