Post

New research · Ophthalmology
Frontiers in ophthalmology · 12h
Cohort studyFrontiers in ophthalmology · 2026

Peripapillary hyperreflective ovoid mass-like structure in arteritic versus nonarteritic anterior ischemic optic neuropathy.

Marius B Maartensson, Andreas Worm Bendtsen, Michael Stormly Hansen … Steffen Hamann
Read paper
OphthalmologyCohort study

PHOMS was more common in arteritic than nonarteritic anterior ischemic optic neuropathy, but not significantly

Peripapillary hyperreflective ovoid mass-like structure in arteritic versus nonarteritic anterior ischemic optic neuropathy.

Marius B Maartensson … Steffen Hamann
Frontiers in ophthalmology · 2026
Background

A peripapillary hyperreflective ovoid mass-like structure (PHOMS) is an optical coherence tomography (optical coherence tomography) specific finding associated with axoplasmic stasis in various optic neuropathies.

Methods

In this exploratory retrospective, age-matched study, patients with arteritic anterior ischemic optic neuropathy and nonarteritic AION (nonarteritic AION) enrolled in two prior prospective studies between March 2021 and August 2024 were included.

n = 22 eyes
Results

in this small study, PHOMS (a swelling sign on eye scans) was seen in over a third of arteritic AION eyes

OR 2.57 (95% CI 0.36 to 18.33)
null = 10.3618.33
CI crosses the null - not significant
More results

PHOMS was observed in both arteritic anterior ischemic optic neuropathy and nonarteritic AION.

The estimated odds ratio for PHOMS presence in arteritic anterior ischemic optic neuropathy compared with nonarteritic AION was 2.57 (95% CI, 0.36-18.33; p = 0.635).

More results

Bruch's membrane opening diameter was similar between groups (arteritic anterior ischemic optic neuropathy: 1546.78 ± 134.14 μm; nonarteritic AION: 1507.27 ± 133.95 μm), while mean peripapillary retinal nerve fiber layer thickness was larger in arteritic anterior ischemic optic neuropathy than in nonarteritic AION.

“
Conclusion

DISCUSSION: The observation of PHOMS across ischemic optic neuropathy subtypes suggests that PHOMS in AION may reflect axoplasmic disturbance related to the ischemic insult itself rather than the underlying disease etiology, although confirmation in larger, prospective studies is warranted.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment