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New research · Ophthalmology
The British journal of ophthalmology · 11h
ObservationalThe British journal of ophthalmology · 2026

Ischemic optic neuropathy with semaglutide: global observational analysis of sex- and formulation-specific risk.

Moiz Lakhani, Abdullah Al-Ani, Marko Popovic … Edward Margolin
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OphthalmologyObservational

Wegovy is associated with nearly 5-fold higher odds of ischemic optic neuropathy than Ozempic.

Ischemic optic neuropathy with semaglutide: global observational analysis of sex- and formulation-specific risk.

Moiz Lakhani … Edward Margolin
The British journal of ophthalmology · 2026
Background

Ischaemic optic neuropathy (ischaemic optic neuropathy) is a rare but vision-threatening complication recently linked to GLP-1 receptor agonists, particularly semaglutide.

Methods

Using over 30 million reports from the FDA Adverse Event Reporting System (2017-2024), we evaluated formulation- and sex-specific associations.

n = 31 774
AOR 4.74
Results
AOR 4.74
Odds of ischemic optic neuropathy were nearly 5 times higher with Wegovy than Ozempic.
n = 31 774
More results

Among 31 774 semaglutide cases, Wegovy demonstrated the strongest signal for ischaemic optic neuropathy (reporting odds ratio (reporting odds ratio)=74.89) compared with Ozempic (reporting odds ratio=18.81).

“
Conclusion

These findings highlight a potential dose-dependent safety concern that warrants urgent prospective evaluation to guide prescribing and regulatory policy.

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