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New research · Ophthalmology
Annals of clinical and translational neurology · 12h
Cohort studyAnnals of clinical and translational neurology · 2026

Paramagnetic Rim Lesions Are Associated With Trans-Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis.

Abdul Jaber Tayem, Angel Liu, Sargis Manukyan … Omar Al-Louzi
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OphthalmologyCohort study

Paramagnetic rim lesions in optic radiations linked to markedly higher trans-synaptic degeneration index

Paramagnetic Rim Lesions Are Associated With Trans-Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis.

Abdul Jaber Tayem … Omar Al-Louzi
Annals of clinical and translational neurology · 2026
Purpose

We investigated associations between rTSD, paramagnetic rim lesions (paramagnetic rim lesions), and longitudinal visual disability in people with multiple sclerosis (pwMS) using a novel optical coherence tomography (optical coherence tomography) based biomarker of rTSD.

Methods

PwMS, non-multiple sclerosis neurological disease controls, and healthy controls underwent optical coherence tomography, multiparametric brain MRI, and clinical assessments.

n = 49 controls
4.5-fold
Results
4.5-fold
damaged optic-radiation tissue linked to much stronger signs of nerve-cell die-back
n = 49 controls
More results

PwMS had higher rTSD than healthy (p = 0.006) and non-multiple sclerosis controls (p = 0.009).

African American race (p = 0.02) and longer disease duration (p = 0.005) were associated with higher baseline rTSD.

More results

Longitudinally, each unit/year progression in rTSD was associated with a -0.07 dB/year decline in hemifield sensitivity (p = 0.005) and a 10.8-fold increase in the odds of expanded disability status scale score progression (p = 0.022).

Higher body mass index was associated with faster rTSD progression longitudinally (p = 0.02).

“
Conclusion · 1 of 2

Paramagnetic rim lesions in the OR, African American race, disease duration, and higher BMI are associated with rTSD in pwMS.

Conclusion · 2 of 2

Longitudinal increase in rTSD is associated with worsening visual loss and clinical disability progression in multiple sclerosis.

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