Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD…

Cross-sectionalNeurology(R) neuroimmunology & neuroinflammation· May 2026

Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS.

Angeliki G Filippatou, Georgios Gakis, Anna Bacchetti … Elias S Sotirchos

Neuro-ophthalmologyCross-sectionalDiagnosis

Greater retinal thinning after optic neuritis correlates with more ganglion cell than inner plexiform layer loss

Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS.

Angeliki G Filippatou … Elias S Sotirchos

Neurology(R) neuroimmunology & neuroinflammation · May 2026

Background

Optic neuritis (optic neuritis) is a common manifestation of multiple sclerosis (multiple sclerosis), aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder (AQP4+NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

Purpose

In this study, we aimed to examine the relative contribution of ganglion cell and inner plexiform thinning to overall GCIPL thinning in MS-optic neuritis, AQP4-optic neuritis, and MOGAD-optic neuritis eyes.

Methods

For the cross-sectional analysis, multiple sclerosis, AQP4+NMOSD, and MOGAD participants with a history of optic neuritis >6 months prior and healthy controls (healthy controls) underwent retinal imaging.

n = 66 eyes

Results

eyes that lost more overall thickness also lost relatively more ganglion cells than inner plexiform layer

MD -1.01 (95% CI -1.59 to -0.44)

null 0

-1.59

-0.44

CI excludes the null - significant

More results

In the cross-sectional cohort, ganglion cell and inner plexiform volumes were lower in AQP4-optic neuritis (n = 30 eyes) and MOGAD-optic neuritis (n = 47 eyes), as compared with MS-optic neuritis (n = 66 eyes), but did not differ between AQP4-optic neuritis and MOGAD-optic neuritis eyes.

More results

AQP4-optic neuritis and MOGAD-optic neuritis eyes had a lower ganglion cell/GCIPL ratio compared with MS-optic neuritis, with no significant difference between AQP4-optic neuritis and MOGAD-optic neuritis.

“

Conclusion

Our findings may help shed light into dynamics of inner retinal layer atrophy after optic neuritis.

Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS.

Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS.

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