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New research · Ophthalmology
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 12h
Cohort studyJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2026

The Association Between Uveitis and Optic Neuritis in Central Nervous System Demyelinating Disorders: A Multi-Institutional Cohort Study.

Jamie L Surgent-Nahay, Muhammad Z Chauhan, Alexander S Kwok … Ahmed B Sallam
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OphthalmologyCohort study

Optic neuritis linked to nearly double the rate of uveitis in demyelinating disease

The Association Between Uveitis and Optic Neuritis in Central Nervous System Demyelinating Disorders: A Multi-Institutional Cohort Study.

Jamie L Surgent-Nahay … Ahmed B Sallam
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2026
Background

Uveitis and optic neuritis related to demyelinating disease share similar immune mechanisms and can have deleterious visual consequences.

Methods

Retrospective cohort study using a health records aggregate.

Results

optic neuritis nearly doubles the risk of developing uveitis (eye inflammation)

HR 1.99 (95% CI 1.57 to 2.52)
null 1
1.57
2.52
CI excludes the null - significant
More results

The 5-year cumulative incidence of any uveitis among patients with optic neuritis in patients with multiple sclerosis was 0.986% (95% CI 0.846-1.15) compared to 0.543% (95% CI 0.437-0.676) in those without optic neuritis (log-rank P < 0.0001), with a HR of 1.95 (95% CI 1.51-2.53).

More results

Intermediate uveitis demonstrated the strongest associations with optic neuritis across study groups.

“
Conclusion

Optic neuritis is a clinically meaningful risk factor for uveitis in patients with central nervous system demyelinating disease, underscoring the need for careful ophthalmic surveillance in this population.

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