Visual Outcomes and Retinal Nerve Fiber Layer Changes Following Methanol Induced Optic Neuropathy: A…

Cohort studyNeuro-ophthalmology (Aeolus Press)· 2026

Visual Outcomes and Retinal Nerve Fiber Layer Changes Following Methanol Induced Optic Neuropathy: A Covid-19 Era Experience.

Mohammad Shirvani, Mohammad Mohammadi, Mohammadreza Khalili … Alireza Attar

RetinaCohort studyPrognosisQ3IF 0.8

Most methanol optic neuropathy survivors had good visual acuity at one-year follow-up.

Visual Outcomes and Retinal Nerve Fiber Layer Changes Following Methanol Induced Optic Neuropathy: A Covid-19 Era Experience.

Mohammad Shirvani … Alireza Attar

Neuro-ophthalmology (Aeolus Press) · 2026 · Q3 in Ophthalmology

Background

Methanol-induced optic neuropathy (MON) is a serious and potentially blinding condition with significant public health concerns.

Purpose

The current study aimed to assess the potential association between arterial blood gas parameters and long-term changes of retinal nerve fiber layer (retinal nerve fiber layer) in survivors of acute methanol poisoning.

Methods

This prospective study was conducted on patients hospitalized with diagnosis of acute methanol poisoning at Ali Asghar Hospital, Shiraz, Iran, between 27 June 2020 and 12 August 2021 in COVID-19 era.

n = 61 patients

Results

share of patients whose vision recovered to a good level after one year

Baseline VA ≥5/10

67.2%

1-year VA ≥5/10

87.7%

More results

Optic disc swelling was noted in 29 patients (47.54%), while 32 (52.46%) had normal optic discs.

Most patients presented on Day 2 (34.43%) and Day 1 (32.79%) post-poisoning.

Also, significant retinal nerve fiber layer thinning was observed across superior, nasal, inferior, and temporal quadrants ( p < .001).

More results

Lower arterial H, decreased bicarbonate levels, and higher anion gap were significantly associated with retinal nerve fiber layer thinning and worse visual outcomes ( p < .001).

“

Conclusion

Optical coherence tomography remains an essential tool for monitoring optic nerve damages in patients with MON.

Visual Outcomes and Retinal Nerve Fiber Layer Changes Following Methanol Induced Optic Neuropathy: A Covid-19 Era Experience.

Visual Outcomes and Retinal Nerve Fiber Layer Changes Following Methanol Induced Optic Neuropathy: A Covid-19 Era Experience.

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